The compact system gives healthcare professionals control over the nitrous oxide concentration while allowing patients to receive the gas mixture as they breathe through the disposable breathing circuit.
Available in three configurations, Nitronox Plus gives healthcare professionals the flexibility to choose the system that best fits their practice needs:
The demand-flow system delivers the selected nitrous oxide and oxygen mixture in response to the patient’s inhalation. Patients remain conscious and spontaneously breathing during administration.
For gynecology practices, Nitronox Plus provides an additional patient-comfort option for in-office procedures, including hysteroscopy, endometrial biopsy, IUD insertion or removal, LEEP, and endometrial ablation.
In a 2026 randomized, placebo-controlled study (n=214) of women who underwent office hysteroscopy, patients who inhaled N2O reported reduced intraprocedural pain and improved satisfaction.1
Select nitrous oxide concentrations from 0% up to 70% (depending on which Nitronox Plus system you choose) to help tailor delivery to the patient, procedure, and level of support needed.
Nitrous oxide takes effect quickly and typically wears off within minutes after administration ends, supporting efficient in-office workflows.
Built-in safety features, demand-flow delivery, and the ability to switch to 100% oxygen when needed all help support confidence use in the office setting.
The use of nitrous oxide may result in occupational exposure. For information on nitrous oxide exposure in occupational settings, including guidelines, refer to recommendations from the National Institute for Occupational Safety and Health (NIOSH), the American Conference of Governmental Industrial Hygienists (ACGIH), and the Occupational Safety and Health Administration (OSHA).
CAUTION: US Federal law restricts this device to sale by or on the order of a physician. Rx Only. The Nitronox Plus system is to be used by a medical professional trained in the use and administration of nitrous oxide and oxygen gases. Indications, contraindications, warnings and instructions for use can be
found in the product labeling supplied with each device or visit https://www.porterinstrument.com/medical-support.
INDICATION FOR USE: The Nitronox Plus is intended to provide a mixture of N2O/O2, on demand, to a conscious, spontaneously breathing patient. The Nitronox Plus is designed for use with adult and pediatric patients and is not intended to be used with infants or neonates.
See Indications, Safety, and Warning InformationThe Nitronox Plus system is manufactured by Parker Hannifin Corporation, 245 Township Line Road Hatfield, PA 19440 USA and is distributed in the USA by Axora Medical, Inc.
1Razdolsky, Sabina MD; Yaniv-Tamir, Rina MD; Raz, Merav MD; Kolp-Asis, Shanny MD; Katz, Tova RN; Elbaz, Loren MD; Tzur, Tamar MD. Nitrous Oxide for Pain Management in Office Hysteroscopy: A Randomized Placebo-Controlled Trial. Obstetrics & Gynecology ():10.1097/AOG.0000000000006282, April 9, 2026. | DOI: 10.1097/AOG.0000000000006282.
Considering moving more gynecologic procedures into your office? Let’s talk about how Nitronox Plus adds a flexible option for supporting patient comfort and also the efficiency of in-office procedures.
Every patient and procedure is different. Nitronox Plus offers adjustable and fixed demand-flow configurations to help practices select an approach that fits their clinical and procedural needs.
The use of nitrous oxide may result in occupational exposure. For information on nitrous oxide exposure in occupational settings, including guidelines, refer to recommendations from the National Institute for Occupational Safety and Health (NIOSH), the American Conference of Governmental Industrial Hygienists (ACGIH), and the Occupational Safety and Health Administration (OSHA).
Considering moving more gynecologic procedures into your office? Let’s talk about how Nitronox Plus adds a flexible option for supporting patient comfort and also the efficiency of in-office procedures.
The Nitronox Plus system is manufactured by Parker Hannifin Corporation, 245 Township Line Road Hatfield, PA 19440 USA and is distributed in the USA by Axora Medical, Inc.
With a comprehensive portfolio of minimally invasive solutions spanning diagnosis through treatment, Axora Medical gives you more options to support personalized patient care.
Schedule a demoWith a comprehensive portfolio of minimally invasive solutions spanning diagnosis through treatment, Axora Medical gives you more options to support personalized patient care.
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